Chapter 1: Conceptualization First some history: Kraepelin is the profound grade in this chapter. Differentiated manic-depressive disease from mania praecox (SCZ). unify melancholia (DEP) and circular psychoses (BPAD, SAFD) into one category. His fundamental insight was that yield is mention. Bleueler woolly the distinction again, putting SCZ and BPAD on a spectrum. SCZ sx were key and affective sx were non-specific. He set the stage for the unipolar-bipolar distinction. unipolar vs. bipolar: G/J spend much time rock that unipolar-bipolar belief is less helpful than the idea of recurrence. Heterogeneity: Unipolar illness very heterogeneous group. So is bipolar. Early mixture schemes (1) turn out different epidemiology between MD, Md, dM and dm groups. Rates: umteen studies show that unipolar:bipolar ~1:1. So what is the unipolar/bipolar distinction: Phenomenology of Depression| bipolar| Unipolar| inhering Course| | | Age of onset| Young| elderly| | press range| Wider range| # sequences| more(prenominal)| little| Length initiative| piteouser| Longer| Cycle length| Longer| shorter| Precipitant of sequence| more than important at onset| ?| Inter-episode mood lability| more| less(prenominal)| | | | Marital Status| Not a RF| RF| | | | Epedimiology| | | Life time risk| 1.5%| 10-15%| Gender| M=F| F>M| SA| much| less(prenominal)| | | | genetic science| More hereditary| less(prenominal)| | | | Biological| | | paroxysm aesthesia| Less| More| Sleep duration| Long| terse| Seasonal| D-fall/winter M-spring/summer| D-spring| | | | Pharm| | | Response to AD| Less| More| Speed of response to AD| More| Less| Tolerance to ADs| More freq| Less freq| Switch w/ ADs| More| Less| Prophylactic response to ADs| Less| More| close to notes on mania: 1) unipolar mania is probably opulent (<10% of BPAD). 2) Primacy of mania (2): all depression follows excitation r eturn (mania, hypomania,...If you want to ge! t a full essay, order it on our website: OrderCustomPaper.com
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